The Growth of Newcastle Disease Virus in Isolated Chorio- Allantoic Membranes

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Date
1953
Authors
Scott, G.R.
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Scott, G. R.
Abstract
The original plan of study __ 4 biochemical investigation of the growth of virus.. In the past 4 years the nutrition group of the Poultry Department of the University of Wiaconsin have explored and developed procedures for inducing deficiencies and excesses of nutritive in embryonatinq eggs., A folic acid analog 4-aminopetyiglutamics acid (aminopterin) was chosen for the study of viral metabolism because . it is asociated with inhibition of the synthesis of thymine and purine bases which, in turn, are necessary for nucleic acid synthesis Snell and Craven,a (195.0) had shown that minute amount. of aminopterin would inhibit development of the chicken embryo, Professor Craven,_ made. their experimental data available.
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