Investigation of mitoch ndrial carrier proteins of Trypanosoma congolens strains characterized for their sensitivity / resistance to Isometamidium

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Date
2009/2010
Authors
EVANS NJERU SIMON
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Trypanosoma Congolense
Abstract
Tsetse - transmitted African trypanosomiasis is one of the major constrains on expansion of livestock industries in Africa, with Trypanosoma congolense being the most pathogenic trypanosome species infecting livestock. The treatment and prophylaxis of African animal trypanosomiasis in cattle, sheep and goats is dependent on the use of three main trypanocidal drugs, namely; diminazene aceturate, homidium and isometamidium. Isometamidium has been used in the field for several decades both prophylactically and therapeutically in the treatment of livestock suffering from T. congolense infections. The drug usually accumulates and compartmentalizes in the kinetoplast DNA (kDNA) of the parasite. There is a growing concern that the effectiveness of chemotherapy will be significantly reduced due to the emergence of drug resistance occasioned by the inappropriate drug use practices, with drug resistance presently reported in 17 African countries.
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