Comparative Pathogenesis and Immunochemical Analysis of Fasciola Gigantica Infections in Cattle and Sheep

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Date
1995
Authors
Leonard W.W
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Kenya Agricultural Research Institute
Abstract
Accurate economic quantification of the effects of Fasciola gigantica infections in cattle and sheep is essential to justify allocation of resources for control programmes. The present studies considered the comparative pathogenesis and economic loss caused by F. gigantica infection in young cattle and sheep of different breeds. Young cattle (Friesian and Boran) and sheep (Dorper and Red Maasai) were infected with single doses of F. gigantica metacercariae to produce chronic infections in cattle and acute, subacute and chronic infections in sheep. The animals were monitored parasitologically, biochemically and serologically. Immunochemical analysis of F. gigantica excretions/secretions using Western blotting and 35S_methionine biosynthetic radio-labelling were carried out with a view to identifying polypeptides of potential use in early prepatent diagnosis and protection and also to determine if there were any apparent species or breed differences in humoral antibody response to the parasite which may correlate with the differences in susceptibility/resistance to infection noted in the two species.
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