Aggravation of Pathogenesis Mediated by Ochratoxln A In Mice infected with Trypanosoma Brucei Rhodesiense

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Date
2009
Authors
Kagira, J.M.
Ngerenwa, J.J.N.
Kibugu, J.K.
Muchiri, M.W.
Makumi, J.N.
Gathumbi, J.K.
Mwangi, J.N.
Mdachi, R.E.
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Abstract
Mice fed 1· 5 mg ochratoxin A (OTA) per kg body weight and infected with Trypanosoma brucei rhodesiense were compared with trypanosome-infected placebo-fed and uninfected OTA-fed controls. Uninfected OTA-fed mice showed fever, lethargy, facial and eyelid oedemas, mild hepatitis and nephritis, and high survival. Infected placebo-fed controls had mean pre-patent period (PPP) of 3·26 days, lethargy, dyspnoea, fever, facial and scrotal oedema, survival of 33-65 days, reduced red cell counts (RCC: 10·96-6·87 x 106 cells/,ul of blood), packed cell volume (PCV: 43'19-26, 36 %), haemoglobin levels (Hb: 13'37-7·92 g/dL) and mean corpuscular volume (MCV) of 37·96-41'31 fL, hepatosplenomegaly, generalized oedemas, heart congestion, hepatitis and nephritis. Compared to infected placebo-fed controls, infected OTA-fed mice had significantly (P< 0'05) shorter mean PPP (2' 58 days), reduced survival (6-47 days) , more pronounced fever and dyspnoea. The latter had significantly (P<0'05) reduced RCC (10'74-4'56 x 106 cells/,ul of blood), PCV (43'90- 20'78%), Hb (13'06-5'74 g/dL), increased MCV (39' 10-43 '97 fL), severe generalized oedemas, haemorrhages, congestion, hepatic haemosiderosis, hepatitis, nephritis, endocarditis, pericarditis and exclusively, splenic macrophage and giant cell hyperplasia, expanded red pulp and splenic erythrophagocytosis. It was concluded that OT A aggravated the pathogenesis of T. b. rhodesiense infection in mice, and should therefore be taken into consideration during trypanosomosis control programmes.
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Journal Of Vector Borne Diseases, 136, pp. 272-281