Studies on Rinderpest Culture Vaccine The Stability of the Reconstituted product

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Date
1971
Authors
Plowright, W.
Rampton, C.S.
Herniman, K.A.J.
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Abstract
The stability of rinderpest cell-culture vaccine was studied after 20o-fold dilutiolt of the reconstituted, lyophilized product. Virus diluted in water showed an immediate loss of infectivity ranging from about 50% to 90% at temperatures between 4° and 37°C. Saline solutions, including 0'85% NaCI, prevented these losses and also resulted in a higher subsequetlt stability. Exposure to diffused daylight or artificial light increased the rate of inactivation of virus by 1'5 too 3'7 times, depending on the intensity of illumination; light of wavelengths 4500 to 5400 A appeared to be active in this respect. The results are discussed in relation to precautions which should be taken in the field use of vaccine or during mallipulation of virus in the laboratory.
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East African Agricultural And Forestry Journal, 12 (1), p. 40-46
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