Effect of multiple treatment of cattle harbouring drug-resistant Trypanosomacongolense on the infectivity andtransmissibility of the parasites for Glossina morsitans centralis

Thumbnail Image
Aladji D
Journal Title
Journal ISSN
Volume Title
Aladji D
In order to defme the duration following treatment of cattle with diminazene aceturate that the drug influences the tsetse infectivity and transmissibility of drug-resistant T congolense, six Boran cattle were infected with T congolense IL 3338. At the first peak of para sitaemi a different groups of 120 teneral Glossina morsitans centralis were fed once on each animal, just before treatment with diminazene aceturate at a dose of 3.5 mg kg· b.w. Thereafter, six different batches of 120 teneral G. m. centralis were fed on each animal on one occasion on days 1,2,3, 7, 14 and 21 after treatment. After 28 days maintenance on goats, flies extruding metacyclic trypanosomes were used in mouse transmission tests, and all flies were dissected to determine the infection rates. Diminazene showed a marked inhibitory effect on the infectivity of T congolense IL 3338 for G. m. centralis for the first three days following treatment and a moderate inhibitory effect for seven days following treatment. In contrast, the drug had no effect on the transmissibility of mature T congolense IL 3338 infections in G. m. centralis to mice in any of the groups of flies.