Dissertation Christopher Kulova Ngichabe 1992

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Date
1992
Authors
Ngichabe, K. C.
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Christopher Kulova Ngichabe
Abstract
Live virus vectored-vaccines represent one of the great achievements of recombinant DNA (DNA) technology resulting from knowledge and understanding of the molecular basis of replication, gene expression and pathogenesis of candidate virus vectors. Any virus can be considered as a potential vector for heterologous genes. The choice depends on the species targeted for vaccination (human or animal) and specific valuable attributes, such as the ease with which DNA manipulations of heterologous gene insertion and selection of recombinant viruses are made, the natural biology (host range), attenuation of infectivity, and the immune response of the host.
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