Studies on Suramin Resistance in Kenyan Stocks of Trypanosoma Evansi

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Kenya Trypanosomiasis Research Institute
Although. trypanosomes parasitise many different vertebrate hosts, their importance lies in their role in causing disease in man and his domesticated livestock in both the Old and New World. Trypanosomes of economic importance can be divided into two groups according to the mode of their transmission; cyclically transmitted trypanosomes have part of their developmental cycle in an insect vector; while for mechanically transmitted trypanosomes, the insect vector plays a purely physical role in transferring parasites from one host to another, without the parasite undergoing any developmental changes. In the Old World, T. rhodesiense and T. gambiense are two species of medical importance that cause East and West African forms of sleeping sickness respectively. These two trypanosome species are cyclically transmitted by tsetse flies of the genus Glossina. Amongst trypanosomes of veterinary importance T. brucei, T. vivax and T. congolense are cyclically transmitted and cause a disease in livestock known as Nagana. T. vivax is found also in South America where it is mechanically transmitted by biting flies. T. evansi, the cause of Surra, is transmitted by biting flies while, uniquely for trypanosomes, T. equiperdum, the cause of Dourine, is transmitted ill coitu.