Trypanosome Non-Specific Antibody Responses During Trypanosoma Congolense Infection Of Cattle

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Date
1998
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Ministry of Agriculture
Abstract
Trypanosome infections of cattle are characterized by concomitant increase in serum IgM, development of antibodies reacting with non-trypanosome antigens and an increase in the proportion of CDS + B cells in peripheral blood and spleen. It is not known whether the three events are related. In mice and humans, CDS + B cells have been shown to predominantly produce IgM antibodies that are polyreactive in nature. This experiment was initiated first to confirm whether trypanosome non-specific antibodies develop during the course of Trypanosoma congoiense infections of susceptible Boran or resistant N'Dama cattle. In addition, to investigate whether a different trypanosome species, Trypanosoma vivax, can r also induce these antibodies. Secondly, to investigate whether the CDS+ B cells, which increase during trypanosome infections of cattle, are the source of the trypanosome non-specific antibodies observed.
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