Characterization of Trypanosome Field Isolated from Cattle in Ghibe, Ethiopia

No Thumbnail Available
Date
1992
Authors
Codia V
Journal Title
Journal ISSN
Volume Title
Publisher
Codia V
Abstract
Twelve trypanosome isolates collected from cattle in Ghibe, Ethiopia, in July 1989, were characterised in Horan (Bos indicus) cattle for their drug sensitivities. Twelve out of twelve infections in experimental calves relapsed following treatment with 7.0 mg diminazene aceturate/kg body weight (b. w.). After the 12 infections had relapsed the calves were treated with 0.5 mg isometamidium chloride/kg b.w.; 11112 infections relapsed. These 11 parasitaemic calves were subsequently treated with 1.0 mg homidium chloride/kg b. w .; 11111 infections relapsed. The findings indicated that, at the time the 12 aforementioned isolates were collected, there was a high prevalence of trypanosome populations in Ghibe which expressed resistance to diminazene, isometamidium and homidium. Furthermore, for at least one isolate, the multidrug-resistance phenotype was also expressed at the clonal level.
Description
Keywords
Citation
Collections