Erythrophagocytosis and the effects of stimulated macrophages on trypanosome brucei and the role of nitric oxide

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Date
1996
Authors
Annete I N
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Annete I N
Abstract
The purpose of this study was to investigate the effect of nitric oxide on Trypanosoma bruce; and Trypanosoma congo/ense in a cell free system and in activated macrophage cultures. SNAP, a nitric oxide donor, caused killing of T. bruce; at concentrations of 0.25 mM and above after 18 hours incubation. A concentration of 0.1 mM had a trypanostatic effect, causing a 70% reduction in numbers. Concentrations of 0.05 mM and lower had no trypanostatic effect. T. congo/ense epimastigote forms appeared to be more resistant to nitric oxide than T. bruce;, with parasites being found alive even after for 18 hours in 5 mM SNAP.
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